It is said that 16th c. theologian Martin Luther once sat in his study for hours to meditate on this passage. For hours he sat oblivious to the world around him. Finally, someone heard him say, “God forsaking God . . . no one can understand that” and he went on about his business.
The great 19th c. preacher, C.H. Spurgeon, preached a message on this passage and said, “I think I can understand the words, "My God, my God, why have you forsaken me?" as they are written by David in the 22nd Psalm; but the same words, "My God, my God, why have you forsaken me?" when uttered by Jesus on the cross, I cannot comprehend, so I shall not pretend to be able to explain them.”